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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2AK4
All Species:
8.79
Human Site:
S714
Identified Species:
19.33
UniProt:
Q9P2K8
Number Species:
10
Phosphosite Substitution
Charge Score:
0.3
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9P2K8
NP_001013725.2
1649
186838
S714
S
S
V
E
W
S
T
S
G
E
R
S
A
S
A
Chimpanzee
Pan troglodytes
XP_001140245
1649
186793
S714
S
S
V
E
W
S
T
S
G
E
R
S
A
S
A
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_535431
1633
184740
S717
I
L
S
S
V
E
W
S
T
S
G
E
R
S
A
Cat
Felis silvestris
Mouse
Mus musculus
Q9QZ05
1648
186468
T712
S
S
S
V
E
W
S
T
S
A
E
R
S
T
S
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518247
1608
180821
E673
V
E
W
S
T
S
C
E
R
S
P
G
A
F
A
Chicken
Gallus gallus
XP_421203
1656
188583
W720
V
L
T
S
S
V
E
W
S
T
S
C
E
R
S
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002667149
1483
168725
S611
S
D
S
S
E
A
L
S
T
P
E
R
P
S
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001120977
1130
130476
N258
S
A
S
N
I
N
N
N
E
N
G
N
I
D
E
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_785160
1605
181469
E727
G
V
G
R
G
A
R
E
V
P
L
A
V
N
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LX30
1241
140303
E369
H
E
L
G
I
L
S
E
E
V
L
D
L
A
S
Baker's Yeast
Sacchar. cerevisiae
P15442
1659
190175
N692
S
S
S
D
F
E
E
N
D
L
L
D
Q
S
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
N.A.
89.7
N.A.
90.5
N.A.
N.A.
74.7
72.3
N.A.
52.6
N.A.
N.A.
27.9
N.A.
40.4
Protein Similarity:
100
99.9
N.A.
94.3
N.A.
94.9
N.A.
N.A.
84.4
84.5
N.A.
67.4
N.A.
N.A.
44
N.A.
59.4
P-Site Identity:
100
100
N.A.
20
N.A.
13.3
N.A.
N.A.
20
0
N.A.
20
N.A.
N.A.
6.6
N.A.
0
P-Site Similarity:
100
100
N.A.
20
N.A.
46.6
N.A.
N.A.
20
6.6
N.A.
26.6
N.A.
N.A.
33.3
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.5
26.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.7
46.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
0
0
19
0
0
0
10
0
10
28
10
37
% A
% Cys:
0
0
0
0
0
0
10
0
0
0
0
10
0
0
0
% C
% Asp:
0
10
0
10
0
0
0
0
10
0
0
19
0
10
0
% D
% Glu:
0
19
0
19
19
19
19
28
19
19
19
10
10
0
10
% E
% Phe:
0
0
0
0
10
0
0
0
0
0
0
0
0
10
0
% F
% Gly:
10
0
10
10
10
0
0
0
19
0
19
10
0
0
0
% G
% His:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
10
0
0
0
19
0
0
0
0
0
0
0
10
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
19
10
0
0
10
10
0
0
10
28
0
10
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
10
0
10
10
19
0
10
0
10
0
10
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
19
10
0
10
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% Q
% Arg:
0
0
0
10
0
0
10
0
10
0
19
19
10
10
10
% R
% Ser:
55
37
46
37
10
28
19
37
19
19
10
19
10
46
46
% S
% Thr:
0
0
10
0
10
0
19
10
19
10
0
0
0
10
0
% T
% Val:
19
10
19
10
10
10
0
0
10
10
0
0
10
0
0
% V
% Trp:
0
0
10
0
19
10
10
10
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _